Receptor tyrosine kinases Tyro3, Axl, and Mertk differentially contribute to antibody-induced arthritis

L Gao, C He, A Yang, H Zhou, Q Lu, RB Birge… - Cell Communication and …, 2023 - Springer
… Similarly, the agonists of TAMs alleviate collagen-induced rheumatoid … Therapeutic
efficacy of Tyro3, Axl, and Mer tyrosine kinase agonists in collagen-induced arthritis. …

[HTML][HTML] New insights into the role of Tyro3, Axl, and Mer receptors in rheumatoid arthritis

S Pagani, M Bellan, D Mauro, LM Castello… - Disease …, 2020 - hindawi.com
Tyrosine kinase receptors Tyro3, Axl, and Mer are members of the TAM family. … Therapeutic
efficacy of Tyro3, Axl, and Mer tyrosine kinase agonists in collagen-induced arthritis,” Arthritis

Tyro3/Axl/Mertk-deficient mice develop bone marrow edema which is an early pathological marker in rheumatoid arthritis

CEJ Waterborg, MI Koenders, PLEM van Lent… - PLoS …, 2018 - journals.plos.org
… We have found that both AXL and MER play a suppressive role by alleviating joint …
Therapeutic efficacy of Tyro3, Axl, and Mer tyrosine kinase agonists in collagen-induced arthritis

[HTML][HTML] Selective increment of synovial soluble TYRO3 correlates with disease severity and joint inflammation in patients with rheumatoid arthritis

J Vullings, JP Vago, CEJ Waterborg… - Journal of Immunology …, 2020 - hindawi.com
tyrosine kinase family consists out of Tyro3, Axl, and Mer (… levels of the soluble Mer tyrosine
kinase receptor in systemic … and nephritis,” Arthritis Research & Therapy, vol. 13, no. 2, p. …

Therapeutic targeting of the functionally elusive TAM receptor family

YR Miao, EB Rankin, AJ Giaccia - Nature Reviews Drug Discovery, 2023 - nature.com
TYRO3, AXL (also known as UFO) and MERTK comprise the TAM receptor tyrosine kinase
(… In particular, these enveloped viruses use PVEERs, including AXL, MER and TYRO3, to …

[PDF][PDF] Role of the Gas6/TAM System as a Disease Marker and Potential Drug Target

PP Sainaghi - downloads.hindawi.com
… interaction with three tyrosine kinase receptors: Tyro3, Axl, and … Tyrosine kinase receptors
Tyro3, Axl, and Mer are members … agonists in collagen-induced arthritis,” Arthritis and Rheuma…

Tyro3, Axl, Mertk receptor-mediated efferocytosis and immune regulation in the tumor environment

L Zhou, GK Matsushima - International Review of Cell and Molecular …, 2021 - Elsevier
… , including Tyro3, Axl, and Mertk (TAM receptor tyrosine kinase … cells and was also named
c-mer, c-Eyk, Nyk, and Tyro12. … It is plausible that agonist of miR335 expression may reduce …

Apoptotic cell clearance components in inflammatory arthritis

K Schneider, S Arandjelovic - Immunological Reviews, 2023 - Wiley Online Library
… a neutralizing antibody during different stages of collagen- induced arthritis (CIA). When …
Therapeutic efficacy of Tyro3, Axl, and Mer tyrosine kinase agonists in collagen- induced arthritis

Gas6/Axl Axis Activation Dampens the Inflammatory Response in Osteoarthritic Fibroblast-like Synoviocytes and Synovial Explants

JP Vago, N Valdrighi, EN Blaney-Davidson… - Pharmaceuticals, 2023 - mdpi.com
… In a model of collagen-induced arthritis, our group … Gas6-based treatment of OA patients
might be efficacious in … used to determine protein expression of Axl, Mer, and Tyro3. …

Protective Role of the MER Tyrosine Kinase via Efferocytosis in Rheumatoid Arthritis Models

CEJ Waterborg, S Beermann, MGA Broeren… - Frontiers in …, 2018 - frontiersin.org
Collagen-induced arthritis (CIA) mice were treated with MER-specific agonistic …
Therapeutic efficacy of Tyro3, Axl, and Mer tyrosine kinase agonists in collagen-induced arthritis